| Viernes 19 de febrero de 2021: | |||||
| Fiorentina | – | 3 | – | 0 | |
| Cagliari | – | Torino | 0 | – | 1 |
| Sábado 20 de febrero de 2021: | |||||
| Lazio | – | Sampdoria | 1 | – | 0 |
| Genoa | – | Hellas Verona | 2 | – | 2 |
| Sassuolo | – | Bologna | 1 | – | 1 |
| Domingo 21 de febrero de 2021: | |||||
| Parma | – | Udinese | 2 | – | 2 |
| Milan | – | Inter de Milán | 0 | – | 3 |
| Atalanta | – | Napoli | 4 | – | 2 |
| Benevento Calcio | – | Roma | 0 | – | 0 |
| Lunes 22 de febrero de 2021: | |||||
| Juventus | – | Crotone | 19:45 | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Inter de Milán | 23 | 16 | 5 | 2 | 57-24 | 53 |
| 2. | Milan | 23 | 15 | 4 | 4 | 45-28 | 49 |
| 3. | Roma | 23 | 13 | 5 | 5 | 47-35 | 44 |
| 4. | Atalanta | 23 | 12 | 7 | 4 | 53-31 | 43 |
| 5. | Lazio | 23 | 13 | 4 | 6 | 38-30 | 43 |
| 6. | Juventus | 21 | 12 | 6 | 3 | 41-19 | 42 |
| 7. | Napoli | 22 | 13 | 1 | 8 | 47-25 | 40 |
| 8. | Sassuolo | 23 | 9 | 8 | 6 | 37-34 | 35 |
| 9. | Hellas Verona | 23 | 9 | 7 | 7 | 30-26 | 34 |
| 10. | Sampdoria | 23 | 9 | 3 | 11 | 33-34 | 30 |
| 11. | Genoa | 23 | 6 | 8 | 9 | 26-33 | 26 |
| 12. | Bologna | 23 | 6 | 7 | 10 | 30-37 | 25 |
| 13. | Udinese | 23 | 6 | 7 | 10 | 25-33 | 25 |
| 14. | Fiorentina | 23 | 6 | 7 | 10 | 25-35 | 25 |
| 15. | Benevento Calcio | 23 | 6 | 7 | 10 | 25-42 | 25 |
| 16. | 23 | 6 | 6 | 11 | 30-41 | 24 | |
| 17. | Torino | 23 | 3 | 11 | 9 | 33-41 | 20 |
| 18. | Cagliari | 23 | 3 | 6 | 14 | 24-41 | 15 |
| 19. | Parma | 23 | 2 | 8 | 13 | 17-45 | 14 |
| 20. | Crotone | 22 | 3 | 3 | 16 | 23-52 | 12 |
