| Viernes 17 de septiembre de 2021: | |||||
| Celta de Vigo | – | Cadiz | 1 | – | 2 |
| Sábado 18 de septiembre de 2021: | |||||
| Rayo Vallecano | – | Getafe | 3 | – | 0 |
| Atlético de Madrid | – | Athletic de Bilbao | 0 | – | 0 |
| Elche | – | Levante | 1 | – | 1 |
| Alavés | – | Osasuna | 0 | – | 2 |
| Domingo 19 de septiembre de 2021: | |||||
| RCD Mallorca | – | Villarreal | 0 | – | 0 |
| Real Sociedad | – | Sevilla | 0 | – | 0 |
| Betis | – | Espanyol | 2 | – | 2 |
| Valencia | – | Real Madrid | 1 | – | 2 |
| Lunes 20 de septiembre de 2021: | |||||
| Barcelona | – | Granada | 19:00 | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Real Madrid | 5 | 4 | 1 | 0 | 15-7 | 13 |
| 2. | Atlético de Madrid | 5 | 3 | 2 | 0 | 7-4 | 11 |
| 3. | Valencia | 5 | 3 | 1 | 1 | 10-4 | 10 |
| 4. | Real Sociedad | 5 | 3 | 1 | 1 | 6-4 | 10 |
| 5. | Athletic de Bilbao | 5 | 2 | 3 | 0 | 4-1 | 9 |
| 6. | Sevilla | 4 | 2 | 2 | 0 | 5-1 | 8 |
| 7. | Osasuna | 5 | 2 | 2 | 1 | 6-6 | 8 |
| 8. | RCD Mallorca | 5 | 2 | 2 | 1 | 3-3 | 8 |
| 9. | Rayo Vallecano | 5 | 2 | 1 | 2 | 8-5 | 7 |
| 10. | Barcelona | 3 | 2 | 1 | 0 | 7-4 | 7 |
| 11. | Betis | 5 | 1 | 3 | 1 | 6-6 | 6 |
| 12. | Elche | 5 | 1 | 3 | 1 | 3-3 | 6 |
| 13. | Cadiz | 5 | 1 | 2 | 2 | 6-8 | 5 |
| 14. | Villarreal | 4 | 0 | 4 | 0 | 2-2 | 4 |
| 15. | Levante | 5 | 0 | 4 | 1 | 6-7 | 4 |
| 16. | Espanyol | 5 | 0 | 3 | 2 | 3-5 | 3 |
| 17. | Granada | 4 | 0 | 2 | 2 | 2-7 | 2 |
| 18. | Celta de Vigo | 5 | 0 | 1 | 4 | 4-10 | 1 |
| 19. | Getafe | 5 | 0 | 0 | 5 | 1-8 | 0 |
| 20. | Alavés | 4 | 0 | 0 | 4 | 1-10 | 0 |
