| Sábado 25 de septiembre de 2021: | |||||
| Chelsea | – | Manchester City | 0 | – | 1 |
| Manchester United | – | Aston Villa | 0 | – | 1 |
| Everton | – | Norwich City | 2 | – | 0 |
| Watford | – | Newcastle United | 1 | – | 1 |
| Leeds United | – | West Ham United | 1 | – | 2 |
| Leicester City | – | Burnley | 2 | – | 2 |
| – | Liverpool | 3 | – | 3 | |
| Domingo 26 de septiembre de 2021: | |||||
| Southampton | – | Wolverhampton | 0 | – | 1 |
| Arsenal | – | Tottenham Hotspur | 3 | – | 1 |
| Lunes 27 de septiembre de 2021: | |||||
| Crystal Palace | – | Brighton & Hove Albion | 19:00 | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Liverpool | 6 | 4 | 2 | 0 | 15-4 | 14 |
| 2. | Manchester City | 6 | 4 | 1 | 1 | 12-1 | 13 |
| 3. | Chelsea | 6 | 4 | 1 | 1 | 12-2 | 13 |
| 4. | Manchester United | 6 | 4 | 1 | 1 | 13-5 | 13 |
| 5. | Everton | 6 | 4 | 1 | 1 | 12-7 | 13 |
| 6. | Brighton & Hove Albion | 5 | 4 | 0 | 1 | 7-4 | 12 |
| 7. | West Ham United | 6 | 3 | 2 | 1 | 13-8 | 11 |
| 8. | Aston Villa | 6 | 3 | 1 | 2 | 9-7 | 10 |
| 9. | 6 | 2 | 3 | 1 | 8-5 | 9 | |
| 10. | Arsenal | 6 | 3 | 0 | 3 | 5-10 | 9 |
| 11. | Tottenham Hotspur | 6 | 3 | 0 | 3 | 4-9 | 9 |
| 12. | Watford | 6 | 2 | 1 | 3 | 7-9 | 7 |
| 13. | Leicester City | 6 | 2 | 1 | 3 | 7-10 | 7 |
| 14. | Wolverhampton | 6 | 2 | 0 | 4 | 3-5 | 6 |
| 15. | Crystal Palace | 5 | 1 | 2 | 2 | 5-8 | 5 |
| 16. | Southampton | 6 | 0 | 4 | 2 | 4-7 | 4 |
| 17. | Newcastle United | 6 | 0 | 3 | 3 | 7-14 | 3 |
| 18. | Leeds United | 6 | 0 | 3 | 3 | 6-14 | 3 |
| 19. | Burnley | 6 | 0 | 2 | 4 | 5-11 | 2 |
| 20. | Norwich City | 6 | 0 | 0 | 6 | 2-16 | 0 |
