| Sábado 30 de octubre de 2021: | |||||
| Leicester City | – | Arsenal | 0 | – | 2 |
| Burnley | – | 3 | – | 1 | |
| Liverpool | – | Brighton & Hove Albion | 2 | – | 2 |
| Watford | – | Southampton | 0 | – | 1 |
| Manchester City | – | Crystal Palace | 0 | – | 2 |
| Newcastle United | – | Chelsea | 0 | – | 3 |
| Tottenham Hotspur | – | Manchester United | 0 | – | 3 |
| Domingo 31 de octubre de 2021: | |||||
| Norwich City | – | Leeds United | 1 | – | 2 |
| Aston Villa | – | West Ham United | 1 | – | 4 |
| Lunes 1 de noviembre de 2021: | |||||
| Wolverhampton | – | Everton | 20:00 | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Chelsea | 10 | 8 | 1 | 1 | 26-3 | 25 |
| 2. | Liverpool | 10 | 6 | 4 | 0 | 29-8 | 22 |
| 3. | Manchester City | 10 | 6 | 2 | 2 | 20-6 | 20 |
| 4. | West Ham United | 10 | 6 | 2 | 2 | 20-11 | 20 |
| 5. | Manchester United | 10 | 5 | 2 | 3 | 19-15 | 17 |
| 6. | Arsenal | 10 | 5 | 2 | 3 | 12-13 | 17 |
| 7. | Brighton & Hove Albion | 10 | 4 | 4 | 2 | 11-11 | 16 |
| 8. | Tottenham Hotspur | 10 | 5 | 0 | 5 | 9-16 | 15 |
| 9. | Everton | 9 | 4 | 2 | 3 | 15-14 | 14 |
| 10. | Leicester City | 10 | 4 | 2 | 4 | 15-17 | 14 |
| 11. | Wolverhampton | 9 | 4 | 1 | 4 | 9-9 | 13 |
| 12. | 10 | 3 | 3 | 4 | 12-12 | 12 | |
| 13. | Crystal Palace | 10 | 2 | 6 | 2 | 13-14 | 12 |
| 14. | Southampton | 10 | 2 | 5 | 3 | 9-12 | 11 |
| 15. | Aston Villa | 10 | 3 | 1 | 6 | 14-19 | 10 |
| 16. | Watford | 10 | 3 | 1 | 6 | 12-18 | 10 |
| 17. | Leeds United | 10 | 2 | 4 | 4 | 10-17 | 10 |
| 18. | Burnley | 10 | 1 | 4 | 5 | 10-16 | 7 |
| 19. | Newcastle United | 10 | 0 | 4 | 6 | 11-23 | 4 |
| 20. | Norwich City | 10 | 0 | 2 | 8 | 3-25 | 2 |
