| Viernes 19 de noviembre de 2021: | |||||
| Levante | – | Athletic de Bilbao | 0 | – | 0 |
| Sábado 20 de noviembre de 2021: | |||||
| Celta de Vigo | – | Villarreal | 1 | – | 1 |
| Sevilla | – | Alavés | 2 | – | 2 |
| Atlético de Madrid | – | Osasuna | 1 | – | 0 |
| Barcelona | – | Espanyol | 1 | – | 0 |
| Domingo 21 de noviembre de 2021: | |||||
| Getafe | – | Cádiz | 4 | – | 0 |
| Granada | – | Real Madrid | 1 | – | 4 |
| Elche | – | Betis | 0 | – | 3 |
| Real Sociedad | – | Valencia | 20:00 | ||
| Lunes 22 de noviembre de 2021: | |||||
| Rayo Vallecano | – | RCD Mallorca | 20:00 | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Real Madrid | 13 | 9 | 3 | 1 | 32-14 | 30 |
| 2. | Sevilla | 13 | 8 | 4 | 1 | 23-9 | 28 |
| 3. | Real Sociedad | 13 | 8 | 4 | 1 | 19-10 | 28 |
| 4. | Atlético de Madrid | 13 | 7 | 5 | 1 | 22-13 | 26 |
| 5. | Betis | 14 | 7 | 3 | 4 | 22-17 | 24 |
| 6. | Rayo Vallecano | 13 | 6 | 2 | 5 | 19-14 | 20 |
| 7. | Barcelona | 13 | 5 | 5 | 3 | 20-15 | 20 |
| 8. | Athletic de Bilbao | 13 | 4 | 7 | 2 | 11-8 | 19 |
| 9. | Osasuna | 14 | 5 | 4 | 5 | 14-18 | 19 |
| 10. | Valencia | 13 | 4 | 5 | 4 | 21-20 | 17 |
| 11. | Espanyol | 14 | 4 | 5 | 5 | 14-14 | 17 |
| 12. | Villarreal | 13 | 3 | 7 | 3 | 15-13 | 16 |
| 13. | RCD Mallorca | 13 | 3 | 6 | 4 | 13-19 | 15 |
| 14. | Alavés | 13 | 4 | 2 | 7 | 10-17 | 14 |
| 15. | Celta de Vigo | 14 | 3 | 4 | 7 | 14-18 | 13 |
| 16. | Cádiz | 14 | 2 | 6 | 6 | 12-23 | 12 |
| 17. | Granada | 13 | 2 | 5 | 6 | 12-20 | 11 |
| 18. | Elche | 14 | 2 | 5 | 7 | 11-20 | 11 |
| 19. | Getafe | 14 | 2 | 3 | 9 | 10-19 | 9 |
| 20. | Levante | 14 | 0 | 7 | 7 | 12-25 | 7 |
