| Sábado 20 de noviembre de 2021: | |||||
| Atalanta | – | Spezia | 5 | – | 2 |
| Lazio | – | Juventus | 0 | – | 2 |
| Fiorentina | – | Milan | 4 | – | 3 |
| Domingo 21 de noviembre de 2021: | |||||
| Sassuolo | – | Cagliari | 2 | – | 2 |
| Bologna | – | 0 | – | 1 | |
| – | Sampdoria | 0 | – | 2 | |
| Inter de Milán | – | Napoli | 3 | – | 2 |
| Genoa | – | Roma | 19:45 | ||
| Lunes 22 de noviembre de 2021: | |||||
| Hellas Verona | – | Empoli | 17:30 | ||
| Torino | – | Udinese | 19:45 | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Napoli | 13 | 10 | 2 | 1 | 26-7 | 32 |
| 2. | Milan | 13 | 10 | 2 | 1 | 29-15 | 32 |
| 3. | Inter de Milán | 13 | 8 | 4 | 1 | 32-15 | 28 |
| 4. | Atalanta | 13 | 7 | 4 | 2 | 27-17 | 25 |
| 5. | Juventus | 13 | 6 | 3 | 4 | 18-15 | 21 |
| 6. | Lazio | 13 | 6 | 3 | 4 | 25-21 | 21 |
| 7. | Fiorentina | 13 | 7 | 0 | 6 | 20-17 | 21 |
| 8. | Roma | 12 | 6 | 1 | 5 | 21-15 | 19 |
| 9. | Bologna | 13 | 5 | 3 | 5 | 19-24 | 18 |
| 10. | Hellas Verona | 12 | 4 | 4 | 4 | 25-21 | 16 |
| 11. | Empoli | 12 | 5 | 1 | 6 | 18-23 | 16 |
| 12. | Sassuolo | 13 | 4 | 3 | 6 | 19-20 | 15 |
| 13. | 13 | 4 | 3 | 6 | 12-19 | 15 | |
| 14. | Torino | 12 | 4 | 2 | 6 | 15-12 | 14 |
| 15. | Udinese | 12 | 3 | 5 | 4 | 15-18 | 14 |
| 16. | Sampdoria | 13 | 3 | 3 | 7 | 17-25 | 12 |
| 17. | Spezia | 13 | 3 | 2 | 8 | 15-31 | 11 |
| 18. | Genoa | 12 | 1 | 6 | 5 | 17-24 | 9 |
| 19. | Cagliari | 13 | 1 | 4 | 8 | 15-28 | 7 |
| 20. | 13 | 2 | 1 | 10 | 10-28 | 7 |
