| Viernes 26 de noviembre de 2021: | |||||
| Athletic de Bilbao | – | Granada | 2 | – | 2 |
| Sábado 27 de noviembre de 2021: | |||||
| Alavés | – | Celta de Vigo | 1 | – | 2 |
| Valencia | – | Rayo Vallecano | 1 | – | 1 |
| RCD Mallorca | – | Getafe | 0 | – | 0 |
| Villarreal | – | Barcelona | 1 | – | 3 |
| Domingo 28 de noviembre de 2021: | |||||
| Betis | – | Levante | 3 | – | 1 |
| Espanyol | – | Real Sociedad | 1 | – | 0 |
| Cadiz | – | Atlético de Madrid | 1 | – | 4 |
| Real Madrid | – | Sevilla | 20:00 | ||
| Lunes 29 de noviembre de 2021: | |||||
| Osasuna | – | Elche | 20:00 | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Real Madrid | 13 | 9 | 3 | 1 | 32-14 | 30 |
| 2. | Atlético de Madrid | 14 | 8 | 5 | 1 | 26-14 | 29 |
| 3. | Real Sociedad | 15 | 8 | 5 | 2 | 19-11 | 29 |
| 4. | Sevilla | 13 | 8 | 4 | 1 | 23-9 | 28 |
| 5. | Betis | 15 | 8 | 3 | 4 | 25-18 | 27 |
| 6. | Rayo Vallecano | 15 | 7 | 3 | 5 | 23-16 | 24 |
| 7. | Barcelona | 14 | 6 | 5 | 3 | 23-16 | 23 |
| 8. | Athletic de Bilbao | 14 | 4 | 8 | 2 | 13-10 | 20 |
| 9. | Espanyol | 15 | 5 | 5 | 5 | 15-14 | 20 |
| 10. | Valencia | 15 | 4 | 7 | 4 | 22-21 | 19 |
| 11. | Osasuna | 14 | 5 | 4 | 5 | 14-18 | 19 |
| 12. | Villarreal | 14 | 3 | 7 | 4 | 16-16 | 16 |
| 13. | Celta de Vigo | 15 | 4 | 4 | 7 | 16-19 | 16 |
| 14. | RCD Mallorca | 15 | 3 | 7 | 5 | 14-22 | 16 |
| 15. | Alavés | 14 | 4 | 2 | 8 | 11-19 | 14 |
| 16. | Granada | 14 | 2 | 6 | 6 | 14-22 | 12 |
| 17. | Cadiz | 15 | 2 | 6 | 7 | 13-27 | 12 |
| 18. | Elche | 14 | 2 | 5 | 7 | 11-20 | 11 |
| 19. | Getafe | 15 | 2 | 4 | 9 | 10-19 | 10 |
| 20. | Levante | 15 | 0 | 7 | 8 | 13-28 | 7 |
