| Sábado 27 de noviembre de 2021: | |||||
| Arsenal | – | Newcastle United | 2 | – | 0 |
| Crystal Palace | – | Aston Villa | 1 | – | 2 |
| Liverpool | – | Southampton | 4 | – | 0 |
| Norwich City | – | Wolverhampton | 0 | – | 0 |
| Brighton & Hove Albion | – | Leeds United | 0 | – | 0 |
| Domingo 28 de noviembre de 2021: | |||||
| – | Everton | 1 | – | 0 | |
| Burnley | – | Tottenham Hotspur | Cancelado | ||
| Leicester City | – | Watford | 4 | – | 2 |
| Manchester City | – | West Ham United | 2 | – | 1 |
| Chelsea | – | Manchester United | 1 | – | 1 |
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Chelsea | 13 | 9 | 3 | 1 | 31-5 | 30 |
| 2. | Manchester City | 13 | 9 | 2 | 2 | 27-7 | 29 |
| 3. | Liverpool | 13 | 8 | 4 | 1 | 39-11 | 28 |
| 4. | West Ham United | 13 | 7 | 2 | 4 | 24-16 | 23 |
| 5. | Arsenal | 13 | 7 | 2 | 4 | 15-17 | 23 |
| 6. | Wolverhampton | 13 | 6 | 2 | 5 | 12-12 | 20 |
| 7. | Tottenham Hotspur | 12 | 6 | 1 | 5 | 11-17 | 19 |
| 8. | Manchester United | 13 | 5 | 3 | 5 | 21-22 | 18 |
| 9. | Brighton & Hove Albion | 13 | 4 | 6 | 3 | 12-14 | 18 |
| 10. | Leicester City | 13 | 5 | 3 | 5 | 20-23 | 18 |
| 11. | Crystal Palace | 13 | 3 | 7 | 3 | 19-19 | 16 |
| 12. | 13 | 4 | 4 | 5 | 17-17 | 16 | |
| 13. | Aston Villa | 13 | 5 | 1 | 7 | 18-21 | 16 |
| 14. | Everton | 13 | 4 | 3 | 6 | 16-20 | 15 |
| 15. | Southampton | 13 | 3 | 5 | 5 | 11-18 | 14 |
| 16. | Watford | 13 | 4 | 1 | 8 | 18-24 | 13 |
| 17. | Leeds United | 13 | 2 | 6 | 5 | 12-20 | 12 |
| 18. | Burnley | 12 | 1 | 6 | 5 | 14-20 | 9 |
| 19. | Norwich City | 13 | 2 | 3 | 8 | 7-27 | 9 |
| 20. | Newcastle United | 13 | 0 | 6 | 7 | 15-29 | 6 |
