| Viernes 26 de noviembre de 2021: | |||||
| Cagliari | – | 1 | – | 1 | |
| Sábado 27 de noviembre de 2021: | |||||
| Empoli | – | Fiorentina | 2 | – | 1 |
| Sampdoria | – | Hellas Verona | 3 | – | 1 |
| Juventus | – | Atalanta | 0 | – | 1 |
| – | Inter de Milán | 0 | – | 2 | |
| Domingo 28 de noviembre de 2021: | |||||
| Udinese | – | Genoa | 0 | – | 0 |
| Milan | – | Sassuolo | 1 | – | 3 |
| Spezia | – | Bologna | 0 | – | 1 |
| Roma | – | Torino | 1 | – | 0 |
| Napoli | – | Lazio | 4 | – | 0 |
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Napoli | 14 | 11 | 2 | 1 | 30-7 | 35 |
| 2. | Milan | 14 | 10 | 2 | 2 | 30-18 | 32 |
| 3. | Inter de Milán | 14 | 9 | 4 | 1 | 34-15 | 31 |
| 4. | Atalanta | 14 | 8 | 4 | 2 | 28-17 | 28 |
| 5. | Roma | 14 | 8 | 1 | 5 | 24-15 | 25 |
| 6. | Juventus | 14 | 6 | 3 | 5 | 18-16 | 21 |
| 7. | Bologna | 14 | 6 | 3 | 5 | 20-24 | 21 |
| 8. | Lazio | 14 | 6 | 3 | 5 | 25-25 | 21 |
| 9. | Fiorentina | 14 | 7 | 0 | 7 | 21-19 | 21 |
| 10. | Hellas Verona | 14 | 5 | 4 | 5 | 28-25 | 19 |
| 11. | Empoli | 14 | 6 | 1 | 7 | 21-26 | 19 |
| 12. | Sassuolo | 14 | 5 | 3 | 6 | 22-21 | 18 |
| 13. | Torino | 14 | 5 | 2 | 7 | 17-14 | 17 |
| 14. | Udinese | 14 | 3 | 6 | 5 | 16-20 | 15 |
| 15. | Sampdoria | 14 | 4 | 3 | 7 | 20-26 | 15 |
| 16. | 14 | 4 | 3 | 7 | 12-21 | 15 | |
| 17. | Spezia | 14 | 3 | 2 | 9 | 15-32 | 11 |
| 18. | Genoa | 14 | 1 | 7 | 6 | 17-26 | 10 |
| 19. | Cagliari | 14 | 1 | 5 | 8 | 16-29 | 8 |
| 20. | 14 | 2 | 2 | 10 | 11-29 | 8 |
