| Sábado 4 de diciembre de 2021: | |||||
| Milan | – | 2 | – | 0 | |
| Roma | – | Inter de Milán | 0 | – | 3 |
| Napoli | – | Atalanta | 2 | – | 3 |
| Domingo 5 de diciembre de 2021: | |||||
| Bologna | – | Fiorentina | 2 | – | 3 |
| – | Hellas Verona | 3 | – | 4 | |
| Spezia | – | Sassuolo | 2 | – | 2 |
| Sampdoria | – | Lazio | 1 | – | 3 |
| Juventus | – | Genoa | 2 | – | 0 |
| Lunes 6 de diciembre de 2021: | |||||
| Empoli | – | Udinese | 17:30 | ||
| Cagliari | – | Torino | 19:45 | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Milan | 16 | 12 | 2 | 2 | 35-18 | 38 |
| 2. | Inter de Milán | 16 | 11 | 4 | 1 | 39-15 | 37 |
| 3. | Napoli | 16 | 11 | 3 | 2 | 34-12 | 36 |
| 4. | Atalanta | 16 | 10 | 4 | 2 | 35-19 | 34 |
| 5. | Juventus | 16 | 8 | 3 | 5 | 22-16 | 27 |
| 6. | Fiorentina | 16 | 9 | 0 | 7 | 27-22 | 27 |
| 7. | Lazio | 16 | 7 | 4 | 5 | 32-30 | 25 |
| 8. | Roma | 16 | 8 | 1 | 7 | 24-19 | 25 |
| 9. | Bologna | 16 | 7 | 3 | 6 | 23-27 | 24 |
| 10. | Hellas Verona | 16 | 6 | 5 | 5 | 32-28 | 23 |
| 11. | Empoli | 15 | 6 | 2 | 7 | 23-28 | 20 |
| 12. | Sassuolo | 16 | 5 | 5 | 6 | 26-25 | 20 |
| 13. | Torino | 15 | 5 | 3 | 7 | 19-16 | 18 |
| 14. | Udinese | 15 | 3 | 7 | 5 | 20-24 | 16 |
| 15. | Sampdoria | 16 | 4 | 3 | 9 | 22-32 | 15 |
| 16. | 16 | 4 | 3 | 9 | 15-29 | 15 | |
| 17. | Spezia | 16 | 3 | 3 | 10 | 17-36 | 12 |
| 18. | Genoa | 16 | 1 | 7 | 8 | 17-31 | 10 |
| 19. | Cagliari | 15 | 1 | 6 | 8 | 16-29 | 9 |
| 20. | 16 | 2 | 2 | 12 | 11-33 | 8 |
