| Viernes 14 de enero de 2022: | |||||
| Brighton & Hove Albion | – | Crystal Palace | 1 | – | 1 |
| Sábado 15 de enero de 2022: | |||||
| Manchester City | – | Chelsea | 1 | – | 0 |
| Burnley | – | Leicester City | Cancelado | ||
| Newcastle United | – | Watford | 1 | – | 1 |
| Norwich City | – | Everton | 2 | – | 1 |
| Wolverhampton | – | Southampton | 3 | – | 1 |
| Aston Villa | – | Manchester United | 2 | – | 2 |
| Domingo 16 de enero de 2022: | |||||
| Liverpool | – | 3 | – | 0 | |
| West Ham United | – | Leeds United | 2 | – | 3 |
| Tottenham Hotspur | – | Arsenal | Cancelado | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Manchester City | 22 | 18 | 2 | 2 | 54-13 | 56 |
| 2. | Liverpool | 21 | 13 | 6 | 2 | 55-18 | 45 |
| 3. | Chelsea | 22 | 12 | 7 | 3 | 45-17 | 43 |
| 4. | West Ham United | 22 | 11 | 4 | 7 | 41-30 | 37 |
| 5. | Arsenal | 20 | 11 | 2 | 7 | 33-25 | 35 |
| 6. | Tottenham Hotspur | 18 | 10 | 3 | 5 | 23-20 | 33 |
| 7. | Manchester United | 20 | 9 | 5 | 6 | 32-29 | 32 |
| 8. | Wolverhampton | 20 | 9 | 4 | 7 | 17-15 | 31 |
| 9. | Brighton & Hove Albion | 20 | 6 | 10 | 4 | 21-21 | 28 |
| 10. | Leicester City | 18 | 7 | 4 | 7 | 31-33 | 25 |
| 11. | Crystal Palace | 21 | 5 | 9 | 7 | 30-31 | 24 |
| 12. | Southampton | 21 | 5 | 9 | 7 | 25-33 | 24 |
| 13. | Aston Villa | 20 | 7 | 2 | 11 | 27-32 | 23 |
| 14. | 21 | 6 | 5 | 10 | 24-33 | 23 | |
| 15. | Leeds United | 20 | 5 | 7 | 8 | 24-39 | 22 |
| 16. | Everton | 19 | 5 | 4 | 10 | 24-34 | 19 |
| 17. | Watford | 19 | 4 | 2 | 13 | 23-37 | 14 |
| 18. | Norwich City | 21 | 3 | 4 | 14 | 10-45 | 13 |
| 19. | Newcastle United | 20 | 1 | 9 | 10 | 20-43 | 12 |
| 20. | Burnley | 17 | 1 | 8 | 8 | 16-27 | 11 |
