| Sábado 19 de febrero de 2022: | |||||
| West Ham United | – | Newcastle United | 1 | – | 1 |
| Aston Villa | – | Watford | 0 | – | 1 |
| Brighton & Hove Albion | – | Burnley | 0 | – | 3 |
| Crystal Palace | – | Chelsea | 0 | – | 1 |
| Arsenal | – | 2 | – | 1 | |
| Liverpool | – | Norwich City | 3 | – | 1 |
| Southampton | – | Everton | 2 | – | 0 |
| Manchester City | – | Tottenham Hotspur | 2 | – | 3 |
| Domingo 20 de febrero de 2022: | |||||
| Leeds United | – | Manchester United | 2 | – | 4 |
| Wolverhampton | – | Leicester City | 2 | – | 1 |
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Manchester City | 26 | 20 | 3 | 3 | 63-17 | 63 |
| 2. | Liverpool | 25 | 17 | 6 | 2 | 64-20 | 57 |
| 3. | Chelsea | 25 | 14 | 8 | 3 | 49-18 | 50 |
| 4. | Manchester United | 26 | 13 | 7 | 6 | 44-34 | 46 |
| 5. | West Ham United | 26 | 12 | 6 | 8 | 45-34 | 42 |
| 6. | Arsenal | 23 | 13 | 3 | 7 | 36-26 | 42 |
| 7. | Wolverhampton | 24 | 12 | 4 | 8 | 23-18 | 40 |
| 8. | Tottenham Hotspur | 23 | 12 | 3 | 8 | 31-31 | 39 |
| 9. | Brighton & Hove Albion | 25 | 7 | 12 | 6 | 25-28 | 33 |
| 10. | Southampton | 25 | 7 | 11 | 7 | 32-37 | 32 |
| 11. | Leicester City | 23 | 7 | 6 | 10 | 37-43 | 27 |
| 12. | Aston Villa | 24 | 8 | 3 | 13 | 31-37 | 27 |
| 13. | Crystal Palace | 25 | 5 | 11 | 9 | 32-36 | 26 |
| 14. | 26 | 6 | 6 | 14 | 27-42 | 24 | |
| 15. | Leeds United | 24 | 5 | 8 | 11 | 29-50 | 23 |
| 16. | Everton | 23 | 6 | 4 | 13 | 28-40 | 22 |
| 17. | Newcastle United | 24 | 4 | 10 | 10 | 26-45 | 22 |
| 18. | Watford | 24 | 5 | 3 | 16 | 24-43 | 18 |
| 19. | Burnley | 22 | 2 | 11 | 9 | 20-29 | 17 |
| 20. | Norwich City | 25 | 4 | 5 | 16 | 15-53 | 17 |
