| Viernes 25 de febrero de 2022: | |||||
| Montpellier | – | Stade Rennes | 2 | – | 4 |
| Sábado 26 de febrero de 2022: | |||||
| Racing Estrasburgo | – | Niza | 0 | – | 0 |
| Paris Saint Germain | – | Saint Etienne | 3 | – | 1 |
| Domingo 27 de febrero de 2022: | |||||
| Mónaco | – | Stade de Reims | 1 | – | 2 |
| – | Girondins de Burdeos | 1 | – | 1 | |
| Metz | – | Nantes | 0 | – | 0 |
| Angers | – | Lens | 1 | – | 2 |
| Stade Brest | – | Lorient | 0 | – | 1 |
| Troyes | – | Olympique de Marsellla | 1 | – | 1 |
| Olympique de Lyon | – | Lille | 0 | – | 1 |
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Paris Saint Germain | 26 | 19 | 5 | 2 | 56-23 | 62 |
| 2. | Olympique de Marsellla | 26 | 13 | 8 | 5 | 39-24 | 47 |
| 3. | Niza | 26 | 14 | 5 | 7 | 37-21 | 46 |
| 4. | Stade Rennes | 26 | 13 | 4 | 9 | 51-25 | 43 |
| 5. | Racing Estrasburgo | 26 | 12 | 7 | 7 | 48-31 | 43 |
| 6. | Lens | 26 | 11 | 7 | 8 | 42-37 | 40 |
| 7. | Nantes | 26 | 11 | 6 | 9 | 34-29 | 39 |
| 8. | Lille | 26 | 10 | 9 | 7 | 33-35 | 39 |
| 9. | Mónaco | 26 | 10 | 8 | 8 | 39-29 | 38 |
| 10. | Olympique de Lyon | 26 | 10 | 9 | 7 | 34-32 | 38 |
| 11. | Montpellier | 26 | 11 | 4 | 11 | 41-38 | 37 |
| 12. | Stade Brest | 26 | 8 | 8 | 10 | 34-38 | 32 |
| 13. | Stade de Reims | 26 | 7 | 10 | 9 | 30-30 | 31 |
| 14. | Angers | 26 | 7 | 8 | 11 | 31-38 | 29 |
| 15. | 26 | 7 | 7 | 12 | 27-42 | 28 | |
| 16. | Lorient | 26 | 5 | 9 | 12 | 21-39 | 24 |
| 17. | Troyes | 26 | 5 | 7 | 14 | 23-41 | 22 |
| 18. | Metz | 26 | 4 | 10 | 12 | 25-45 | 22 |
| 19. | Saint Etienne | 26 | 5 | 7 | 14 | 27-50 | 22 |
| 20. | Girondins de Burdeos | 26 | 4 | 10 | 12 | 38-63 | 22 |
