| Viernes 15 de abril de 2022: | |||||
| Spezia | – | Inter de Milán | 1 | – | 3 |
| Milan | – | Genoa | 2 | – | 0 |
| Sábado 16 de abril de 2022: | |||||
| Cagliari | – | Sassuolo | 1 | – | 0 |
| Sampdoria | – | 1 | – | 2 | |
| Udinese | – | Empoli | 4 | – | 1 |
| Fiorentina | – | 1 | – | 0 | |
| Juventus | – | Bologna | 1 | – | 1 |
| Lazio | – | Torino | 1 | – | 1 |
| Lunes 18 de abril de 2022: | |||||
| Napoli | – | Roma | 17:00 | ||
| Atalanta | – | Hellas Verona | 19:00 | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Milan | 33 | 21 | 8 | 4 | 58-29 | 71 |
| 2. | Inter de Milán | 32 | 20 | 9 | 3 | 68-25 | 69 |
| 3. | Napoli | 32 | 20 | 6 | 6 | 58-26 | 66 |
| 4. | Juventus | 33 | 18 | 9 | 6 | 50-29 | 63 |
| 5. | Roma | 32 | 17 | 6 | 9 | 53-36 | 57 |
| 6. | Lazio | 33 | 16 | 8 | 9 | 65-48 | 56 |
| 7. | Fiorentina | 32 | 17 | 5 | 10 | 53-40 | 56 |
| 8. | Atalanta | 31 | 14 | 9 | 8 | 53-36 | 51 |
| 9. | Sassuolo | 33 | 12 | 10 | 11 | 58-53 | 46 |
| 10. | Hellas Verona | 32 | 12 | 9 | 11 | 56-49 | 45 |
| 11. | Torino | 32 | 10 | 10 | 12 | 36-31 | 40 |
| 12. | Udinese | 31 | 9 | 12 | 10 | 47-49 | 39 |
| 13. | Bologna | 32 | 10 | 8 | 14 | 35-45 | 38 |
| 14. | Empoli | 33 | 8 | 10 | 15 | 42-60 | 34 |
| 15. | Spezia | 33 | 9 | 6 | 18 | 33-57 | 33 |
| 16. | Sampdoria | 33 | 8 | 5 | 20 | 40-56 | 29 |
| 17. | Cagliari | 33 | 6 | 10 | 17 | 31-61 | 28 |
| 18. | Genoa | 33 | 2 | 16 | 15 | 24-54 | 22 |
| 19. | 32 | 5 | 7 | 20 | 26-58 | 22 | |
| 20. | 31 | 4 | 7 | 20 | 25-69 | 19 |
