| Sábado 14 de mayo de 2022: | |||||
| Espanyol | – | Valencia | 1 | – | 1 |
| Domingo 15 de mayo de 2022: | |||||
| Athletic de Bilbao | – | Osasuna | 2 | – | 0 |
| Atlético de Madrid | – | Sevilla | 1 | – | 1 |
| Betis | – | Granada | 2 | – | 0 |
| Celta de Vigo | – | Elche | 1 | – | 0 |
| Cadiz | – | Real Madrid | 1 | – | 1 |
| Getafe | – | Barcelona | 0 | – | 0 |
| Villarreal | – | Real Sociedad | 1 | – | 2 |
| RCD Mallorca | – | Rayo Vallecano | 2 | – | 1 |
| Levante | – | Alavés | 3 | – | 1 |
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Real Madrid | 37 | 26 | 7 | 4 | 80-31 | 85 |
| 2. | Barcelona | 37 | 21 | 10 | 6 | 68-36 | 73 |
| 3. | Atlético de Madrid | 37 | 20 | 8 | 9 | 63-42 | 68 |
| 4. | Sevilla | 37 | 17 | 16 | 4 | 52-30 | 67 |
| 5. | Betis | 37 | 19 | 7 | 11 | 62-40 | 64 |
| 6. | Real Sociedad | 37 | 17 | 11 | 9 | 39-35 | 62 |
| 7. | Villarreal | 37 | 15 | 11 | 11 | 61-37 | 56 |
| 8. | Athletic de Bilbao | 37 | 14 | 13 | 10 | 43-35 | 55 |
| 9. | Osasuna | 37 | 12 | 11 | 14 | 37-49 | 47 |
| 10. | Celta de Vigo | 37 | 12 | 10 | 15 | 43-41 | 46 |
| 11. | Valencia | 37 | 10 | 15 | 12 | 46-53 | 45 |
| 12. | Rayo Vallecano | 37 | 11 | 9 | 17 | 37-46 | 42 |
| 13. | Espanyol | 37 | 10 | 11 | 16 | 40-53 | 41 |
| 14. | Elche | 37 | 10 | 9 | 18 | 37-51 | 39 |
| 15. | Getafe | 37 | 8 | 15 | 14 | 32-38 | 39 |
| 16. | Granada | 37 | 8 | 13 | 16 | 44-61 | 37 |
| 17. | RCD Mallorca | 37 | 9 | 9 | 19 | 34-63 | 36 |
| 18. | Cadiz | 37 | 7 | 15 | 15 | 34-51 | 36 |
| 19. | Levante | 37 | 7 | 11 | 19 | 47-74 | 32 |
| 20. | Alavés | 37 | 8 | 7 | 22 | 31-64 | 31 |
