| Domingo 15 de mayo de 2022: | |||||
| Tottenham Hotspur | – | Burnley | 1 | – | 0 |
| Aston Villa | – | Crystal Palace | 1 | – | 1 |
| Watford | – | Leicester City | 1 | – | 5 |
| Leeds United | – | Brighton & Hove Albion | 1 | – | 1 |
| West Ham United | – | Manchester City | 2 | – | 2 |
| Wolverhampton | – | Norwich City | 1 | – | 1 |
| Everton | – | 2 | – | 3 | |
| Lunes 16 de mayo de 2022: | |||||
| Newcastle United | – | Arsenal | 19:00 | ||
| EQUIPO | J | G | E | P | Goles | Pts | |
| 1. | Manchester City | 37 | 28 | 6 | 3 | 96-24 | 90 |
| 2. | Liverpool | 36 | 26 | 8 | 2 | 89-24 | 86 |
| 3. | Chelsea | 36 | 20 | 10 | 6 | 73-31 | 70 |
| 4. | Tottenham Hotspur | 37 | 21 | 5 | 11 | 64-40 | 68 |
| 5. | Arsenal | 36 | 21 | 3 | 12 | 56-45 | 66 |
| 6. | Manchester United | 37 | 16 | 10 | 11 | 57-56 | 58 |
| 7. | West Ham United | 37 | 16 | 8 | 13 | 59-48 | 56 |
| 8. | Wolverhampton | 37 | 15 | 6 | 16 | 37-40 | 51 |
| 9. | Leicester City | 36 | 13 | 9 | 14 | 57-57 | 48 |
| 10. | Brighton & Hove Albion | 37 | 11 | 15 | 11 | 39-43 | 48 |
| 11. | 37 | 13 | 7 | 17 | 47-54 | 46 | |
| 12. | Crystal Palace | 36 | 10 | 15 | 11 | 47-43 | 45 |
| 13. | Aston Villa | 36 | 13 | 5 | 18 | 49-50 | 44 |
| 14. | Newcastle United | 36 | 11 | 10 | 15 | 40-61 | 43 |
| 15. | Southampton | 36 | 9 | 13 | 14 | 41-61 | 40 |
| 16. | Everton | 36 | 10 | 6 | 20 | 39-59 | 36 |
| 17. | Leeds United | 37 | 8 | 11 | 18 | 40-78 | 35 |
| 18. | Burnley | 36 | 7 | 13 | 16 | 32-50 | 34 |
| 19. | Watford | 37 | 6 | 5 | 26 | 33-75 | 23 |
| 20. | Norwich City | 37 | 5 | 7 | 25 | 23-79 | 22 |
